Administration of Brincidofovir and Convalescent Plasma in a Patient With Ebola Virus Disease

Clin Infect Dis. 2015 Sep 15;61(6):969-73. doi: 10.1093/cid/civ395. Epub 2015 May 19.

Abstract

From 2014 to May 2015, >26 000 Ebola virus disease (EVD) cases were reported from West Africa. We present a patient with EVD who received brincidofovir and convalescent plasma. The relative contributions of supportive care, investigational therapies, and patient's immune-response on survival could not be determined. Randomized trials are needed.

Keywords: Ebola; investigational therapies; trials.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Africa, Western
  • Alanine Transaminase / blood
  • Antibodies, Viral / blood
  • Antiviral Agents / administration & dosage*
  • Aspartate Aminotransferases / blood
  • Bilirubin / blood
  • Cytosine / administration & dosage
  • Cytosine / analogs & derivatives*
  • Hemorrhagic Fever, Ebola / therapy*
  • Humans
  • Immunization, Passive*
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Leukocyte Count
  • Male
  • Organophosphonates / administration & dosage*
  • Plasma*
  • Platelet Count
  • RNA, Viral / blood
  • Randomized Controlled Trials as Topic
  • Treatment Outcome
  • Viral Load

Substances

  • Antibodies, Viral
  • Antiviral Agents
  • Immunoglobulin G
  • Immunoglobulin M
  • Organophosphonates
  • RNA, Viral
  • brincidofovir
  • Cytosine
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Bilirubin