The effects of bromazepam over the central and frontal areas during a motor task: an EEG study

Arq Neuropsiquiatr. 2015 Apr;73(4):321-9. doi: 10.1590/0004-282X20150011. Epub 2015 Apr 1.

Abstract

The present study investigates the influence of bromazepam while executing a motor task. Specifically, we intend to analyze the changes in alpha absolute power under two experimental conditions, bromazepam and placebo. We also included analyses of theta and beta frequencies. We collected electroencephalographic data before, during, and after motor task execution. We used a Two Way ANOVA to investigate the condition (PL × Br6 mg) and moment (pre and post) variables for the following electrodes: Fp1, Fp2, F7, F3, Fz, F4, F8, C3, CZ and C4. We found a main effect for condition on the electrodes FP1, F7, F3, Fz, F4, C3 and CZ, for alpha and beta bands. For beta band we also found a main effect for condition on the electrodes Fp2, F8 and C4; for theta band we identified a main effect for condition on C3, Cz and C4 electrodes. This finding suggests that the motor task did not have any influence on the electrocortical activity in alpha, and that the existing modifications were a consequence due merely to the drug use. Despite its anxiolytic and sedative action, bromazepam did not show any significant changes when the individuals executed a finger extension motor task.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Analysis of Variance
  • Anti-Anxiety Agents / pharmacology*
  • Brain Waves / drug effects
  • Bromazepam / pharmacology*
  • Double-Blind Method
  • Electroencephalography / drug effects
  • Female
  • Frontal Lobe / drug effects*
  • Frontal Lobe / physiology
  • Humans
  • Male
  • Motor Activity / drug effects
  • Motor Skills / drug effects*
  • Reference Values
  • Somatosensory Cortex / drug effects*
  • Somatosensory Cortex / physiology
  • Task Performance and Analysis
  • Time Factors
  • Young Adult

Substances

  • Anti-Anxiety Agents
  • Bromazepam