Thymic selection: to thine own self be true

Alexandra Kitz; David A Hafler

doi:10.1016/j.immuni.2015.05.007

Thymic selection: to thine own self be true

Immunity. 2015 May 19;42(5):788-9. doi: 10.1016/j.immuni.2015.05.007.

Authors

Alexandra Kitz¹, David A Hafler²

Affiliations

¹ Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
² Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: [email protected].

PMID: 25992854
DOI: 10.1016/j.immuni.2015.05.007

Abstract

It has been shown that self-reactive T cells can be detected in the periphery. In this issue of Immunity, Yu et al. (2015) show that clonal deletion prunes the T cell repertoire but does not eliminate self-reactive T cell clones.

Publication types

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MeSH terms

Animals
CD8-Positive T-Lymphocytes / cytology*
CD8-Positive T-Lymphocytes / immunology*
Clonal Deletion*
Female
Humans
Male