K356dup--an in-frame insertion in the BCR-ABL gene in an imatinib-resistant chronic myeloid leukemia

Int J Lab Hematol. 2012 Dec;34(6):e3-6. doi: 10.1111/j.1751-553x.2012.01443.x.

Authors

M Gniot¹, E M Wasilewska², K Lewandowski³

Affiliations

¹ Department of Hematology, University of Medical Sciences, Poznan, Poland. [email protected].
² Department of Hematology, University of Medical Sciences, Bialystok, Poland.
³ Department of Hematology, University of Medical Sciences, Poznan, Poland.

PMID: 25998099
DOI: 10.1111/j.1751-553x.2012.01443.x

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Dasatinib / therapeutic use
Drug Resistance, Neoplasm / genetics
Female
Fusion Proteins, bcr-abl / antagonists & inhibitors
Fusion Proteins, bcr-abl / genetics
Gene Expression Regulation, Leukemic / drug effects
Humans
Imatinib Mesylate / chemistry
Imatinib Mesylate / pharmacology
Imatinib Mesylate / therapeutic use*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
Models, Molecular
Mutagenesis, Insertional*
Protein Binding
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology
Protein Kinase Inhibitors / therapeutic use
Protein Structure, Tertiary
Proto-Oncogene Proteins c-abl / antagonists & inhibitors
Proto-Oncogene Proteins c-abl / chemistry
Proto-Oncogene Proteins c-abl / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Young Adult

Substances

Protein Kinase Inhibitors
Imatinib Mesylate
Fusion Proteins, bcr-abl
Proto-Oncogene Proteins c-abl
Dasatinib