Malignant Rhabdoid Tumor with Cervical Vertebra Involvement in a Teenage Child: Case Report and Review of the Literature

Pediatr Neurosurg. 2015;50(3):173-8. doi: 10.1159/000430448. Epub 2015 May 14.

Abstract

Malignant rhabdoid tumor (MRT) is a highly malignant and aggressive tumor associated with the kidney that is mainly seen in children under 5 years old, resulting in a rapid fatal outcome. MRT invasion of the cervical vertebra is an extremely rare form of this malignancy. This study presents a case of MRT involving the C4 vertebra and its appendix. A 13-year-old girl was found to have vague neck pain and a mass in the left neck area of the mid-cervical spine. Percutaneous needle biopsy was performed and the histological and immunohistochemical analysis pointed towards a rhabdoid tumor. Chemotherapy and radiotherapy were performed, but the tumor mass progressively enlarged. Tumorectomy was conducted followed by another 6 courses of chemotherapy and (125)I radioactive seed implantation. Unfortunately, the C4 vertebra and its appendix were found to be abnormal 3 months after the end of therapy. The patient received an additional tumorectomy, internal fixation with C4 reconstruction by a combined anterior and posterior approach, and 6 courses of consolidation chemotherapy. She is still alive 40 months since the initial diagnosis and remains asymptomatic 31 months after the surgery.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Cervical Vertebrae / pathology
  • Cervical Vertebrae / surgery*
  • Female
  • Humans
  • Rhabdoid Tumor / diagnosis*
  • Rhabdoid Tumor / surgery*
  • Spinal Neoplasms / diagnosis*
  • Spinal Neoplasms / surgery*