Arrhythmia in stem cell transplantation

Card Electrophysiol Clin. 2015 Jun;7(2):357-70. doi: 10.1016/j.ccep.2015.03.012. Epub 2015 Apr 9.

Abstract

Stem cell regenerative therapies hold promise for treating diseases across the spectrum of medicine. While significant progress has been made in the preclinical stages, the clinical application of cardiac cell therapy is limited by technical challenges. Certain methods of cell delivery, such as intramyocardial injection, carry a higher rate of arrhythmias. Other potential contributors to the arrhythmogenicity of cell transplantation include reentrant pathways caused by heterogeneity in conduction velocities between graft and host as well as graft automaticity. In this article, the arrhythmogenic potential of cell delivery to the heart is discussed.

Keywords: Arrhythmia; Cardiomyocyte; Coupling; Electromechanical; Paracrine; Regeneration; Stem cell.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arrhythmias, Cardiac*
  • Humans
  • Myocytes, Cardiac
  • Stem Cell Transplantation*