An activating ALK gene mutation in ALK IHC-positive/FISH-negative nonsmall-cell lung cancer

Ann Oncol. 2015 Aug;26(8):1800-1. doi: 10.1093/annonc/mdv240. Epub 2015 May 22.

Authors

Y Togashi¹, H Mizuuchi², Y Kobayashi², H Hayashi¹, M Terashima¹, K Sakai¹, E Banno¹, T Mizukami¹, Y Nakamura¹, M A de Velasco¹, Y Fujita¹, S Tomida¹, T Mitsudomi², K Nishio³

Affiliations

¹ Department of Genome Biology, Kinki University Faculty of Medicine, Osaka, Japan.
² Department of Thoracic Surgery, Kinki University Faculty of Medicine, Osaka, Japan.
³ Department of Genome Biology, Kinki University Faculty of Medicine, Osaka, Japan [email protected].

PMID: 26002608
DOI: 10.1093/annonc/mdv240

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Anaplastic Lymphoma Kinase
Carcinoma, Non-Small-Cell Lung / genetics*
Carcinoma, Non-Small-Cell Lung / metabolism
HEK293 Cells
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lung Neoplasms / genetics*
Lung Neoplasms / metabolism
Male
Middle Aged
Mutation
Receptor Protein-Tyrosine Kinases / genetics*
Receptor Protein-Tyrosine Kinases / metabolism

Substances

ALK protein, human
Anaplastic Lymphoma Kinase
Receptor Protein-Tyrosine Kinases