From Soft Self-Healing Gels to Stiff Films in Suckerin-Based Materials Through Modulation of Crosslink Density and β-Sheet Content

Dawei Ding; Paul A Guerette; Jing Fu; Lihong Zhang; Scott A Irvine; Ali Miserez

doi:10.1002/adma.201500280

From Soft Self-Healing Gels to Stiff Films in Suckerin-Based Materials Through Modulation of Crosslink Density and β-Sheet Content

Adv Mater. 2015 Jul 8;27(26):3953-61. doi: 10.1002/adma.201500280. Epub 2015 May 26.

Authors

Dawei Ding^{1

2}, Paul A Guerette^{1

2}, Jing Fu^{1

2}, Lihong Zhang^{1

2}, Scott A Irvine¹, Ali Miserez^{1

2

3}

Affiliations

¹ School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
² Center for Biomimetic Sensor Science (CBSS), Research Technological Plaza, Nanyang Technological University, 50 Nanyang Drive, Singapore, 637553, Singapore.
³ School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.

PMID: 26011516
DOI: 10.1002/adma.201500280

Abstract

Suckerins are block-copolymer-like structural proteins constituting the building blocks of the strong squid sucker-ring teeth. Here, recombinant suckerin-19 is processed into biomaterials spanning a wide range of elasticity, from very soft hydrogels to stiff films with elastic modulus in the gigapascal range. The elasticity is controlled by the interplay between the β-sheet content and induced di-tyrosine crosslinking.

Keywords: crosslinks; di-tyrosine; hydrogels and films; suckerin; β-sheets.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Elasticity*
Fish Proteins / chemistry*
Gels
Humans
Models, Molecular
Protein Structure, Secondary
Rheology

Substances

Fish Proteins
Gels