Cytokines, hormones and growth factors, also defined with the collective name of signaling molecules are key regulating agents of physiological (and also pathological) functions according to the principles of Psycho-Neuro-Endocrine-Immunology (P.N.E.I.). From the latest evidences in the fields of Molecular Biology, P.N.E.I. and nano-concentration, a new medical approach surfaces: the Low Dose Medicine (LDM), a new tool for the study and the design of therapeutic strategies based on immune rebalance interventions. LDM suggest the use of low-doses of activated signaling molecules in order to restore P.N.E.I. homeostatic conditions and an increasing number of scientific evidences of LDM approach efficacy and safety support LDM-based therapeutic approach for the treatment of many dermatological diseases such as Psoriasis Vulgaris, Vitiligo and Atopic Dermatitis.