Strangles in horses can be caused by vaccination with Pinnacle I. N

Vaccine. 2015 Jul 9;33(30):3440-3. doi: 10.1016/j.vaccine.2015.05.009. Epub 2015 May 27.

Abstract

The differentiation of live attenuated vaccine strains from their progenitor and wild-type counterparts is important for ongoing surveillance of product safety and improved guidelines on their use. We utilised a genome sequencing approach to confirm that two cases of strangles in previously healthy horses that had received the Pinnacle I. N. vaccine (Zoetis) were caused by the vaccine strain. Our data shed new light on the safety of this vaccine and suggest that factors beyond the maturity of the animal's immune system influence the development of adverse reactions.

Keywords: Adverse effects; Pinnacle; Reversion; Strangles; Vaccine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacterial Vaccines / administration & dosage
  • Bacterial Vaccines / adverse effects*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Drug Contamination
  • Genome, Bacterial
  • Horse Diseases / chemically induced*
  • Horses
  • Respiratory Tract Infections / chemically induced
  • Respiratory Tract Infections / veterinary*
  • Sequence Analysis, DNA
  • Streptococcal Infections / chemically induced
  • Streptococcal Infections / veterinary*
  • Streptococcus equi
  • Vaccination / adverse effects*

Substances

  • Bacterial Vaccines
  • DNA, Bacterial