Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma

Zhao Ye; Zhiqiang Li; Yongfei Wang; Ying Mao; Ming Shen; Qilin Zhang; Shiqi Li; Liangfu Zhou; Xuefei Shou; Jianhua Chen; Zhijian Song; Zengyi Ma; Zhaoyun Zhang; Yiming Li; Hongying Ye; Chuanxin Huang; Tao Wang; Wenqiang He; Yichao Zhang; Rong Xie; Nidan Qiao; Huijia Qiu; Shan Huang; Meng Wang; Jiawei Shen; Zujia Wen; Wenjin Li; Ke Liu; Juan Zhou; Lin Wang; Jue Ji; Yin Wang; Hong Chen; Haixia Cheng; Zhifeng Shi; Yuqian Zhu; Daoying Geng; Zhenwei Yao; Weijun Tang; Bin Lu; Li Pan; Yi Zhang; Weimin Bao; Jinsong Wu; Kang Zheng; Yongyong Shi; Yao Zhao

doi:10.1038/ng.3322

Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma

Nat Genet. 2015 Jul;47(7):793-7. doi: 10.1038/ng.3322. Epub 2015 Jun 1.

Authors

Zhao Ye¹, Zhiqiang Li², Yongfei Wang¹, Ying Mao¹, Ming Shen¹, Qilin Zhang¹, Shiqi Li¹, Liangfu Zhou¹, Xuefei Shou¹, Jianhua Chen³, Zhijian Song², Zengyi Ma¹, Zhaoyun Zhang⁴, Yiming Li⁴, Hongying Ye⁴, Chuanxin Huang⁵, Tao Wang⁶, Wenqiang He¹, Yichao Zhang¹, Rong Xie¹, Nidan Qiao¹, Huijia Qiu¹, Shan Huang⁶, Meng Wang², Jiawei Shen², Zujia Wen², Wenjin Li², Ke Liu², Juan Zhou², Lin Wang², Jue Ji², Yin Wang⁷, Hong Chen⁷, Haixia Cheng⁷, Zhifeng Shi¹, Yuqian Zhu¹, Daoying Geng⁸, Zhenwei Yao⁸, Weijun Tang⁸, Bin Lu⁴, Li Pan¹, Yi Zhang¹, Weimin Bao¹, Jinsong Wu¹, Kang Zheng¹, Yongyong Shi⁹, Yao Zhao¹

Affiliations

¹ 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
² Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
³ 1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. [2] Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁴ 1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
⁵ Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶ Department of Neurosurgery, Shanghai 5th People's Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
⁷ Department of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
⁸ Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
⁹ 1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. [2] Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3] Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai, China. [4] Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, Shanghai, China. [5] Department of Psychiatry, The First Teaching Hospital of Xinjiang Medical University, Urumqi, China. [6] Shandong Provincial Key Laboratory of Metabolic Disease, the Affiliated Hospital of Qingdao University, Qingdao, China.

PMID: 26029870
DOI: 10.1038/ng.3322

Abstract

Pituitary adenoma is one of the most common intracranial neoplasms, and its genetic basis remains largely unknown. To identify genetic susceptibility loci for sporadic pituitary adenoma, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. We first analyzed genome-wide SNP data in 771 pituitary adenoma cases and 2,788 controls and then carried forward the promising variants for replication in another 2 independent sets (2,542 cases and 3,620 controls in total). We identified three new susceptibility loci below the genome-wide significance threshold (P < 5 × 10(-8)) in the combined analyses: 10p12.31 (rs2359536, P(meta) = 2.25 × 10(-10) and rs10828088, P(meta) = 6.27 × 10(-10)), 10q21.1 (rs10763170, P(meta) = 6.88 × 10(-10)) and 13q12.13 (rs17083838, P(meta) = 1.89 × 10(-8)). This study is the first GWAS to our knowledge on sporadic pituitary adenoma, and our results provide insight into the genetic basis of this disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenoma / genetics*
Adult
Case-Control Studies
Chromosomes, Human, Pair 10 / genetics*
Chromosomes, Human, Pair 13 / genetics*
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Middle Aged
Pituitary Neoplasms / genetics*
Polymorphism, Single Nucleotide*
Sequence Analysis, DNA