Abstract
The radiosensitivity of three drug-resistant sublines of a human epidermoid lung carcinoma growing as xenografts in nude mice was investigated. Drug resistance to vincristine, actinomycin D and cisplatin was developed in vivo by repeated drug treatment. It was found that all three drug-resistant tumour lines were not cross-resistant to irradiation.
MeSH terms
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Animals
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Carcinoma, Squamous Cell / drug therapy
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Carcinoma, Squamous Cell / radiotherapy*
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Cisplatin / pharmacology
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Cobalt Radioisotopes / therapeutic use
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Dactinomycin / pharmacology
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Drug Resistance
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Female
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Humans
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Lung Neoplasms / drug therapy
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Lung Neoplasms / radiotherapy*
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Male
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Mice
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Mice, Nude
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Middle Aged
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Neoplasm Transplantation
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Radiation Tolerance
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Random Allocation
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Vincristine / pharmacology
Substances
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Cobalt Radioisotopes
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Dactinomycin
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Vincristine
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Cisplatin