Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage

Angew Chem Int Ed Engl. 2015 Jul 13;54(29):8449-53. doi: 10.1002/anie.201502430. Epub 2015 Jun 1.

Abstract

Novel isoselenazoles with high glutathione peroxidase (GPx) and peroxiredoxin (Prx) activities provide remarkable cytoprotection to human cells, mainly by exhibiting antioxidant activities in the presence of cellular thiols. The cytotoxicity of the isoselenazoles is found to be significantly lower than that of ebselen, which is being clinically evaluated by several groups for the treatment of reperfusion injuries and stroke, hearing loss, and bipolar disorder. The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species.

Keywords: DNA damage; antioxidants; glutathione peroxidase; reactive oxygen species; selenium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry*
  • Antioxidants / pharmacology
  • Biomimetic Materials / chemistry*
  • Biomimetic Materials / pharmacology
  • Glutathione Peroxidase / chemistry*
  • HEK293 Cells
  • HeLa Cells
  • Humans
  • Organoselenium Compounds / chemistry*
  • Organoselenium Compounds / pharmacology
  • Oxidation-Reduction / drug effects
  • Oxidative Stress / drug effects*
  • Peroxiredoxins / chemistry*
  • Reactive Oxygen Species / metabolism

Substances

  • Antioxidants
  • Organoselenium Compounds
  • Reactive Oxygen Species
  • Peroxiredoxins
  • Glutathione Peroxidase