Three New Sesquiterpene Aryl Esters from the Mycelium of Armillaria mellea

Chien-Chih Chen; Yueh-Hsiung Kuo; Jing-Jy Cheng; Ping-Jyun Sung; Ching-Li Ni; Chin-Chu Chen; Chien-Chang Shen

doi:10.3390/molecules20069994

Three New Sesquiterpene Aryl Esters from the Mycelium of Armillaria mellea

Molecules. 2015 May 29;20(6):9994-10003. doi: 10.3390/molecules20069994.

Authors

Chien-Chih Chen^{1

2}, Yueh-Hsiung Kuo^{3

4}, Jing-Jy Cheng⁵, Ping-Jyun Sung^{6

7}, Ching-Li Ni⁸, Chin-Chu Chen⁹, Chien-Chang Shen¹⁰

Affiliations

¹ Department of Biotechnology, HungKuang University, Sha Lu, Taichung 433, Taiwan. [email protected].
² Department of Nursing, HungKuang University, Sha Lu, Taichung 433, Taiwan. [email protected].
³ Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan. [email protected].
⁴ Department of Biotechnology, Asia University, Taichung 413, Taiwan. [email protected].
⁵ National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Peitou, Taipei 112, Taiwan. [email protected].
⁶ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. [email protected].
⁷ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. [email protected].
⁸ Department of Biotechnology, HungKuang University, Sha Lu, Taichung 433, Taiwan. [email protected].
⁹ Biotechnology Center, Grape King Bio Ltd., Chung Li, Taoyuan 320, Taiwan. [email protected].
¹⁰ National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Peitou, Taipei 112, Taiwan. [email protected].

Abstract

Three new sesquiterpene aryl esters and eight known compounds were isolated from the EtOH extract of the mycelium of Armillaria mellea. The structures of new compounds were established by analysis of their spectroscopic data. Some of the isolates showed cytotoxicity to a variety of cancer cell lines, including MCF-7, H460, HT-29, and CEM.

Keywords: Armillaria mellea; Tricholomataceae; cytotoxicity; sesquiterpene aryl esters.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Armillaria / chemistry*
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Doxorubicin / pharmacology
Esters
Ethanol / chemistry
HT29 Cells
Humans
MCF-7 Cells
Molecular Structure
Mycelium / chemistry*
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology*
Solid Phase Extraction
Solvents / chemistry

Substances

Antineoplastic Agents
Esters
Sesquiterpenes
Solvents
Ethanol
Doxorubicin