Spontaneous Regression of Pulmonary Lymphoepithelioma-Like Carcinoma

Yo Kawaguchi; Takuya Fujita; Jun Hanaoka

doi:10.1016/j.athoracsur.2014.07.088

Spontaneous Regression of Pulmonary Lymphoepithelioma-Like Carcinoma

Ann Thorac Surg. 2015 Jun;99(6):2197-9. doi: 10.1016/j.athoracsur.2014.07.088.

Authors

Yo Kawaguchi¹, Takuya Fujita², Jun Hanaoka³

Affiliations

¹ Division of General Thoracic Surgery, Kohka Public Hospital, Shiga, Japan. Electronic address: [email protected].
² Division of General Thoracic Surgery, Kohka Public Hospital, Shiga, Japan.
³ Division of General Thoracic Surgery, Department of Surgery, Shiga University of Medical Science, Shiga, Japan.

PMID: 26046875
DOI: 10.1016/j.athoracsur.2014.07.088

Abstract

The spontaneous regression of lung cancer is extremely rare. We encountered a case of a 70-year-old man with pulmonary lymphoepithelioma-like carcinoma that regressed without receiving anticancer therapy. The patient had depression during tumor regression, however, and was treated with a serotonin-selective reuptake inhibitor. On histologic examination, CD3(+), CD4(+), and CD8(+) lymphocytes were found to have infiltrated around the tumor. Thus, the serotonin-selective reuptake inhibitor may have activated these lymphocytes to cause spontaneous tumor regression.

Publication types

Case Reports

MeSH terms

Adenocarcinoma, Papillary / diagnosis*
Aged
Biopsy
Follow-Up Studies
Humans
Lung Neoplasms / diagnosis*
Lymphocytes / pathology*
Male
Neoplasm Regression, Spontaneous*
Tomography, X-Ray Computed