Lack of Effect of Platelet Transfusions and Desmopressin on Intracranial Bleeding in a Patient Receiving Ticagrelor

A A Case Rep. 2015 Jun 15;4(12):169-71. doi: 10.1213/XAA.0000000000000156.

Abstract

We describe a case of a 67-year-old man who required emergency surgery for acute intracranial bleeding after having received a loading dose of aspirin and ticagrelor for an acute ST-elevation myocardial infarction. Before and during the craniocervical decompression, the assessment of platelet function was performed using the Multiplate® analyzer. Biological evaluation of platelet function was consistent with the clinical impression, suggesting that platelet transfusion and desmopressin administration in the presence of ticagrelor had very little, if any, hemostatic effect.

Publication types

  • Case Reports

MeSH terms

  • Adenosine / adverse effects
  • Adenosine / analogs & derivatives*
  • Aged
  • Aspirin / adverse effects
  • Combined Modality Therapy
  • Deamino Arginine Vasopressin / administration & dosage*
  • Fatal Outcome
  • Hemostatics / administration & dosage*
  • Humans
  • Intracranial Hemorrhages / etiology
  • Intracranial Hemorrhages / therapy*
  • Male
  • Myocardial Infarction / drug therapy
  • Platelet Activation / drug effects
  • Platelet Aggregation Inhibitors / adverse effects*
  • Platelet Function Tests
  • Platelet Transfusion*
  • Purinergic P2Y Receptor Antagonists / adverse effects
  • Ticagrelor

Substances

  • Hemostatics
  • Platelet Aggregation Inhibitors
  • Purinergic P2Y Receptor Antagonists
  • Deamino Arginine Vasopressin
  • Ticagrelor
  • Adenosine
  • Aspirin