Abstract
Novel non-competitive inhibitors of HIV RT were synthesized by alkylation of 6-substituted purines with different 2-(chloroalkyl)-2-aryl-1,3-dioxolanes and related compounds. The structure-activity relationship within the synthesized compounds was studied.
MeSH terms
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Anti-HIV Agents* / chemical synthesis
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Anti-HIV Agents* / chemistry
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HIV Reverse Transcriptase / antagonists & inhibitors*
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HIV Reverse Transcriptase / chemistry
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HIV-1 / enzymology*
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Humans
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Purines* / chemical synthesis
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Purines* / chemistry
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Reverse Transcriptase Inhibitors* / chemical synthesis
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Reverse Transcriptase Inhibitors* / chemistry
Substances
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Anti-HIV Agents
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Purines
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Reverse Transcriptase Inhibitors
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reverse transcriptase, Human immunodeficiency virus 1
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HIV Reverse Transcriptase