Core-Shell Upconversion Nanoparticle@Metal-Organic Framework Nanoprobes for Luminescent/Magnetic Dual-Mode Targeted Imaging

Adv Mater. 2015 Jul 15;27(27):4075-80. doi: 10.1002/adma.201501779. Epub 2015 Jun 5.

Abstract

Core-shell upconversion nanoparticle@metal-organic framework (UCNP@MOF) nanostructures are constructed by coating hexagonal NaYF4 :Yb,Er nanoparticle (NP) cores with amino-functionalized iron carboxylate MOF shells. These nanostructures combine the near-infrared optical property of the UCNP cores and the T2 -magnetic response (MR) imaging property of the MOF shells. After surface modification, the core-shell nanostructures are demonstrated as high-resolution nanoprobes for targeted luminescence/MR imaging both in vitro and in vivo.

Keywords: biocompatibility; core-shell nanostructures; dual-mode targeted imaging; surface modification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry
  • Cell Line, Tumor
  • Cell Survival
  • Contrast Media / chemical synthesis
  • Contrast Media / chemistry
  • Humans
  • Luminescence
  • Luminescent Measurements / instrumentation
  • Luminescent Measurements / methods*
  • Magnetic Resonance Imaging / instrumentation
  • Magnetic Resonance Imaging / methods*
  • Magnetite Nanoparticles* / chemistry
  • Mice, Inbred BALB C
  • Mice, Nude
  • Microscopy, Confocal
  • Microscopy, Electron, Transmission
  • Neoplasm Transplantation
  • Polyethylene Glycols / chemistry
  • Spectrum Analysis
  • Water / chemistry
  • X-Ray Diffraction

Substances

  • Biocompatible Materials
  • Contrast Media
  • Magnetite Nanoparticles
  • Water
  • Polyethylene Glycols