Excluding T Cells: Is β-Catenin the Full Story?

Siwen Hu-Lieskovan; Blanca Homet Moreno; Antoni Ribas

doi:10.1016/j.ccell.2015.05.014

Excluding T Cells: Is β-Catenin the Full Story?

Cancer Cell. 2015 Jun 8;27(6):749-50. doi: 10.1016/j.ccell.2015.05.014.

Authors

Siwen Hu-Lieskovan¹, Blanca Homet Moreno², Antoni Ribas³

Affiliations

¹ Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, CA 90095, USA.
² Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
³ Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Surgery, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Medical and Molecular Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, CA 90095, USA. Electronic address: [email protected].

PMID: 26058073
DOI: 10.1016/j.ccell.2015.05.014

Abstract

Spranger and colleagues reported recently in Nature an inverse relationship between melanoma intrinsic β-catenin signaling and intratumoral T cell infiltration, providing an explanation for potential mechanisms of T cell exclusion. Further insights are needed into the mechanisms leading to a lack of T cell infiltration of cancers and primary immune resistance.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Humans
Melanoma / immunology*
Melanoma / physiopathology*
Signal Transduction*
T-Lymphocytes / immunology*
Tumor Microenvironment / immunology*
beta Catenin / immunology*

Substances

beta Catenin

Abstract

Publication types

MeSH terms

Substances

Grants and funding