Myelodysplastic Syndrome with 6q Deletion as the Sole Chromosome Abnormality in an Iranian Patient: A Case Report with Review of Literature

Shirin Ferdowsi; Reza Shirkoohi; Gholamreza Toogeh

Myelodysplastic Syndrome with 6q Deletion as the Sole Chromosome Abnormality in an Iranian Patient: A Case Report with Review of Literature

Iran J Public Health. 2013 Oct;42(10):1187-91.

Authors

Shirin Ferdowsi¹, Reza Shirkoohi², Gholamreza Toogeh³

Affiliations

¹ 1. Dept. of Hematology, Iranian Blood Transfusion Organization , Tehran, Iran.
² 2. Dept. of Molecular Genetics, Cancer Research Center, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences , Tehran, Iran.
³ 3. Dept. of Hematology-Oncology and BMT Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences , Tehran, Iran.

PMID: 26060629
PMCID: PMC4436549

Abstract

The myelodysplastic syndrome (MDS) is a highly heterogenous disorder and karyotype analysis is helpful for diagnostic and prognostic estimation. Deletion in long arm chromosome 6 (6q del) as a sole abnormality is a rare event in MDS. This is the first case report of del (6q) as the only observed diagnostic change in Iran. We also reviewed the literature of this cytogenetic lesion.

Keywords: Deletion 6q; Iran; Myelodysplastic syndrome.