Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): modifying serotonin's downstream effects on glutamate and GABA (gamma amino butyric acid) release

CNS Spectr. 2015 Aug;20(4):331-6. doi: 10.1017/S1092852915000334. Epub 2015 Jun 11.

Abstract

Vortioxetine is an antidepressant with multiple pharmacologic modes of action at targets where serotonin neurons connect with other neurons. These actions modify the release of both glutamate and GABA (gamma amino butyric acid) within various brain circuits.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / metabolism
  • Brain / physiology
  • Exocytosis / drug effects*
  • Glutamic Acid / metabolism*
  • Humans
  • Piperazines / pharmacology*
  • Selective Serotonin Reuptake Inhibitors / pharmacology*
  • Serotonin / metabolism*
  • Sulfides / pharmacology*
  • Vortioxetine
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Piperazines
  • Serotonin Uptake Inhibitors
  • Sulfides
  • Serotonin
  • Glutamic Acid
  • Vortioxetine
  • gamma-Aminobutyric Acid