Combining Passive Sampling with Recombinant Receptor-Reporter Gene Bioassays to Assess the Receptor Activity of Victorian Rivers

Bull Environ Contam Toxicol. 2015 Dec;95(6):758-63. doi: 10.1007/s00128-015-1577-6. Epub 2015 Jun 14.

Abstract

This pilot study was initiated to provide new information on the 'hormonal' activity of Victorian rivers. Chemcatcher™ passive sampler systems containing Empore™ C18FF disks were deployed at eight riverine sites near Melbourne. Little estrogenic activity [<0.4-1.8 ng estradiol equivalents (EQ)/disk] and no retinoic acid activity (RAR, all samples <0.8 ng trans-retinoic acid EQ/disk) was observed. Almost all sample extracts showed aryl hydrocarbon receptor activity (from <4 to 29 ng β-naphthoflavone EQ/disk). Overall, the disk extracts were eminently compatible with the bioassay screening technology, enabling the relative levels of 'hormonal activity' to be observed in the surface waters in and around Melbourne. From a practical perspective, the in situ sampling and pre-concentration provided by passive sampling reduces the manual handling risks associated with sample transport, and the number of laboratory operations required to obtain assay-ready solutions for analysis.

Keywords: Aryl hydrocarbon receptor activity; Australia; Chemcatcher passive sampler; Estrogenic activity; Yarra River; Yeast-based two-hybrid recombinant receptor–reporter gene assay activity.

MeSH terms

  • Animals
  • Biological Assay
  • Environmental Monitoring / methods*
  • Genes, Reporter
  • Humans
  • Oryzias / metabolism
  • Pilot Projects
  • Receptors, Aryl Hydrocarbon / chemistry
  • Receptors, Estrogen / chemistry
  • Receptors, Retinoic Acid / chemistry
  • Rivers / chemistry*
  • Victoria
  • Water Pollutants, Chemical / analysis*
  • Water Pollutants, Chemical / chemistry
  • Water Quality
  • Yeasts / metabolism

Substances

  • Receptors, Aryl Hydrocarbon
  • Receptors, Estrogen
  • Receptors, Retinoic Acid
  • Water Pollutants, Chemical