Side-on cupric-superoxo triplet complexes as competent agents for H-abstraction relevant to the active site of PHM

Chem Commun (Camb). 2015 Jul 14;51(55):11134-7. doi: 10.1039/c5cc02332g.

Abstract

Copper complexes with N3S donors mimic the CuM site of copper monooxygenases and react with O2 affording side-on cupric-superoxo complexes capable of H-abstraction from dihydroanthracene and THF. Spectroscopic and DFT data of the Cu-superoxos support a spin triplet ground state for the side-on complexes, as well as a hemilabile thioether.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzimidazoles / chemistry
  • Benzimidazoles / metabolism
  • Catalytic Domain
  • Copper / chemistry
  • Copper / metabolism*
  • Ligands
  • Mixed Function Oxygenases / chemistry
  • Mixed Function Oxygenases / metabolism*
  • Molecular Structure
  • Multienzyme Complexes / chemistry
  • Multienzyme Complexes / metabolism*
  • Nitrogen Compounds / chemistry
  • Nitrogen Compounds / metabolism
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / metabolism*
  • Sulfur Compounds / chemistry
  • Sulfur Compounds / metabolism
  • Superoxides / chemistry
  • Superoxides / metabolism*

Substances

  • Benzimidazoles
  • Ligands
  • Multienzyme Complexes
  • Nitrogen Compounds
  • Organometallic Compounds
  • Sulfur Compounds
  • Superoxides
  • Copper
  • Mixed Function Oxygenases
  • peptidylglycine monooxygenase