A signature for success

Elife. 2015 Jun 16:4:e08773. doi: 10.7554/eLife.08773.

Abstract

The expression pattern of 13 genes can predict whether cancer cells will be sensitive to drugs that inhibit a protein that represses the activity of p53.

Keywords: human; human biology; medicine; p53; predictive signature; translational oncology.

Publication types

  • Comment

MeSH terms

  • Biomarkers / metabolism*
  • Gene Expression Regulation, Neoplastic / drug effects*
  • Humans
  • Isoquinolines / pharmacology*
  • Neoplasms / drug therapy*
  • Patient Selection*
  • Piperazines / pharmacology*
  • Proto-Oncogene Proteins c-mdm2 / antagonists & inhibitors*
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • Biomarkers
  • Isoquinolines
  • Piperazines
  • Tumor Suppressor Protein p53
  • Proto-Oncogene Proteins c-mdm2