New Isoprenylated Phenolic Compounds from Morus laevigata

Meng Wang; Bang-Wei Yu; Mei-Hua Yu; Li-Xin Gao; Jing-Ya Li; He-Yao Wang; Jia Li; Ai-Jun Hou

doi:10.1002/cbdv.201400210

New Isoprenylated Phenolic Compounds from Morus laevigata

Chem Biodivers. 2015 Jun;12(6):937-45. doi: 10.1002/cbdv.201400210.

Authors

Meng Wang¹, Bang-Wei Yu², Mei-Hua Yu¹, Li-Xin Gao², Jing-Ya Li², He-Yao Wang², Jia Li², Ai-Jun Hou³

Affiliations

¹ Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, P. R. China (phone/fax: +86-21-51980005).
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.
³ Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, P. R. China (phone/fax: +86-21-51980005). [email protected].

PMID: 26080739
DOI: 10.1002/cbdv.201400210

Abstract

Two new isoprenylated flavonoids, laevigasins A and B (1 and 2, resp.), and one new isoprenylated 2-arylbenzofuran, leavigasin C (3), together with eight known compounds, 4-11, were isolated from the twigs of Morus laevigata. Their structures were elucidated by spectroscopic methods. Laevigasin A (1) showed significant inhibitory effect on α-glucosidase in vitro. Notabilisin E (5), taxifolin (10), and hultenin (11) inhibited PTP1B phosphatase activity in vitro.

Keywords: Flavonoids; Isoprenylated phenolics; Laevigasins A and B; Leavigasin C; Morus laevigata; Protein tyrosine phosphatase 1B; α-Glucosidase.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Molecular Structure
Morus / chemistry*
Phenols / chemistry
Phenols / isolation & purification*
Plant Extracts / chemistry
Plant Extracts / isolation & purification*

Substances

Phenols
Plant Extracts