Complementing T Cells' Functions: Bringing in Metabolism Matters

Immunity. 2015 Jun 16;42(6):977-9. doi: 10.1016/j.immuni.2015.06.008.

Abstract

Components of the complement system act directly on T cells to alter conventional and regulatory T cell subsets. In this issue of Immunity, Kolev, Dimeloe, Le Friec et al. (2015) provide evidence of a mechanism by which the complement stimulates sustained mTORC1 activation and regulates cellular metabolism.

Publication types

  • Comment

MeSH terms

  • Complement System Proteins / immunology*
  • Hemolytic-Uremic Syndrome / immunology*
  • Humans
  • Large Neutral Amino Acid-Transporter 1 / metabolism*
  • Membrane Cofactor Protein / metabolism*
  • Th1 Cells / physiology*

Substances

  • Large Neutral Amino Acid-Transporter 1
  • Membrane Cofactor Protein
  • Complement System Proteins