ER Stress in Dendritic Cells Promotes Cancer

Christopher S Garris; Mikael J Pittet

doi:10.1016/j.cell.2015.06.006

ER Stress in Dendritic Cells Promotes Cancer

Cell. 2015 Jun 18;161(7):1492-3. doi: 10.1016/j.cell.2015.06.006.

Authors

Christopher S Garris¹, Mikael J Pittet²

Affiliations

¹ Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA; Graduate Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.
² Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA. Electronic address: [email protected].

PMID: 26091029
DOI: 10.1016/j.cell.2015.06.006

Abstract

XBP1 is part of the ER stress response, and when activated in cancer cells, it fosters tumor growth. In this issue of Cell, Cubillos-Ruiz et al. demonstrate that XBP1 in tumor-infiltrating dendritic cells blunts anti-tumor immunity. These findings further imply XBP1 as a relevant target for cancer therapy.

Publication types

Comment

MeSH terms

Animals
DNA-Binding Proteins / metabolism*
Dendritic Cells / pathology*
Endoplasmic Reticulum Stress*
Female
Humans
Ovarian Neoplasms / immunology*
Ovarian Neoplasms / pathology*
Transcription Factors / metabolism*

Substances

DNA-Binding Proteins
Transcription Factors