A Shortcut to Activity-Dependent Transcription

Nikhil Sharma; Harrison W Gabel; Michael E Greenberg

doi:10.1016/j.cell.2015.06.009

A Shortcut to Activity-Dependent Transcription

Cell. 2015 Jun 18;161(7):1496-8. doi: 10.1016/j.cell.2015.06.009.

Authors

Nikhil Sharma¹, Harrison W Gabel¹, Michael E Greenberg²

Affiliations

¹ Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
² Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: [email protected].

PMID: 26091031
DOI: 10.1016/j.cell.2015.06.009

Abstract

Neuronal activity results in the rapid induction of gene transcription through a series of defined molecular events. Madabhushi et al. describe an unexpected role for the cutting of promoter DNA by topoisomerase IIB to facilitate transcription of activity-induced genes.

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MeSH terms

Animals
DNA Breaks, Double-Stranded*
Neurons / metabolism*