Rapid and sensitive analysis of polymorphisms from breastmilk shows that ibuprofen is safe during certain stages of breastfeeding

Acta Paediatr. 2015 Sep;104(9):e420-1. doi: 10.1111/apa.13078. Epub 2015 Jul 28.

Authors

Virginie Rigourd^{1

2}, Jean-Francois Meritet³, Patrick Seraissol⁴, Ammar Amirouche², Taymme Hachem¹, Raphaël Serreau^{2

5}

Affiliations

¹ Human Milk Bank Ile de France and Neonatology Unit, Necker Hospital, Paris, France.
² Medic-Al Network, Necker Hospital, AP-HP Paris, Paris, France.
³ Cochin Necker Immunology Unit Hospital, AP-HP Paris, Paris, France.
⁴ Pharmacokinetic and Clinical Toxicology Purpan Hospital, Toulouse, France.
⁵ Preventive medicine service, Orleans, France.

PMID: 26096518
DOI: 10.1111/apa.13078

No abstract available

Keywords: Milk feeding; Pharmacodynamics; Pharmacokinetics; Pharmacological approach; Premature infant.

MeSH terms

Analgesics, Non-Narcotic / pharmacokinetics*
Breast Feeding
Cytochrome P-450 CYP2C8 / genetics
Cytochrome P-450 CYP2C9 / genetics
Female
Humans
Ibuprofen / pharmacokinetics*
Milk, Human / chemistry*
Polymorphism, Genetic

Substances

Analgesics, Non-Narcotic
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2C8
Ibuprofen