Clinical and pharmacokinetic study of intraperitoneal cisplatin at two dose levels: 100 mg/m2 alone or 200 mg/m2 with i.v. sodium thiosulfate

P Canal; M de Forni; E Chatelut; C Chevreau; N P Johnson; G Houin; R Bugat

Clinical and pharmacokinetic study of intraperitoneal cisplatin at two dose levels: 100 mg/m2 alone or 200 mg/m2 with i.v. sodium thiosulfate

Acta Med Austriaca. 1989;16(3-4):84-6.

Authors

P Canal¹, M de Forni, E Chatelut, C Chevreau, N P Johnson, G Houin, R Bugat

Affiliation

¹ Unités de Pharmacocinétique et de Pharmacologie Clinique, Université Paul Sabatier, Toulouse, France.

PMID: 2609919

Abstract

In 22 patients cisplatin was infused intraperitoneally in 70 cycles using a dose of 100 and 200 mg/m2. The ratio between peritoneal and plasma AUC was between 10 and 20. No patient showed an objective remission.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / drug therapy
Antidotes*
Cisplatin / administration & dosage*
Cisplatin / adverse effects
Cisplatin / pharmacokinetics
Colorectal Neoplasms / drug therapy
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Humans
Infusion Pumps
Infusions, Intravenous
Infusions, Parenteral / instrumentation
Middle Aged
Ovarian Neoplasms / drug therapy
Peritoneal Neoplasms / blood
Peritoneal Neoplasms / drug therapy*
Pilot Projects
Thiosulfates / administration & dosage*

Substances

Antidotes
Thiosulfates
sodium thiosulfate
Cisplatin