OS108. Preeclamptic women display salt sensitivity and cardiovascular damage before their menopause

G Martillotti; M Boulvain; G Wagner; V Othenin-Girard; P Saudan; O P Irion; A Pechère-Bertschi

doi:10.1016/j.preghy.2012.04.109

OS108. Preeclamptic women display salt sensitivity and cardiovascular damage before their menopause

Pregnancy Hypertens. 2012 Jul;2(3):238. doi: 10.1016/j.preghy.2012.04.109. Epub 2012 Jun 13.

Authors

G Martillotti¹, M Boulvain¹, G Wagner², V Othenin-Girard¹, P Saudan³, O P Irion¹, A Pechère-Bertschi²

Affiliations

¹ Obstetrics, University Hospital Geneva, Geneva 4, Switzerland.
² Hypertension Unit, University Hospital, Geneva 4, Switzerland.
³ Nephrology, University Hospital, Geneva 4, Switzerland.

PMID: 26105322
DOI: 10.1016/j.preghy.2012.04.109

Abstract

Introduction: Salt sensitivity is an important cardiovascular risk factor. It has been shown that preeclamptic (PEC) women may not be totally cured after the delivery and keep a higher cardiovascular risk than nonPEC women.

Objectives: We aimed to study the salt sensitivity of the blood pressure in women with a history of severe preeclamspia and women with no history of hypertensive complications.The design was a case control study with intervention, including 42 women recruited 5 to 17 years following delivery.

Methods: 21 women having suffered from a severe preeclampsia before 34 weeks of pregnancy and 19 age, race matched controls women,were randomized to follow for one week a low salt (LS) diet and a high salt (HS) diet (adding 6g NACL/d to usual diet). On day seven of each dietary period, 24h ambulatory blood pressure was recorded, and 24h urine collected in order to measure sodium excretion.Salt sensitivity was assigned if the mean 24h blood pressure increased by ⩾ 3mmHg on a high- compared with a low-salt diet.

Results: Preeclamptic women were aged 39.1(24-49) and controls 40.1(29-49), p=NS.Two of the PEC women already suffered from a cardiovascular event (2coronary events). The PEC women showed a significant increase of the BP and standard deviation (SD) of the BP compared to the controls.10 (47.6%) preeclamptic women showed salt sensitivity (odd ratio 5.4, 95% CI 0.972-30.601;P=0.042).Recurrent preeclampsia was associated with a significantly high risk to salt sensitivity status (OR 5; 95% confidence interval 1.1-31.6).

Conclusion: Severe PEC women display already salt sensitivity of the blood pressure before their menopause and increased variability of the BP. Recurrent preeclampsia is a high risk factor for salt sensitivity and could allow to target this high-risk group at an early stage for preventive measures for cardiovascular disease.