Analysis of 17 Y-STR loci haplotype and Y-chromosome haplogroup distribution in five Chinese ethnic groups

Ying Wang; Chao Liu; Chu-chu Zhang; Ran Li; Yue Li; Xue-ling Ou; Hong-yu Sun

doi:10.1002/elps.201500089

Analysis of 17 Y-STR loci haplotype and Y-chromosome haplogroup distribution in five Chinese ethnic groups

Electrophoresis. 2015 Oct;36(20):2546-52. doi: 10.1002/elps.201500089.

Authors

Ying Wang¹, Chao Liu^{2

3}, Chu-chu Zhang¹, Ran Li¹, Yue Li^{2

3}, Xue-ling Ou¹, Hong-yu Sun¹

Affiliations

¹ Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, P. R. China.
² Guangdong Provincial Key Laboratory of Forensic Genetics, Guangzhou, P. R. China.
³ Guangzhou Institute of Criminal Science and Technology, Guangzhou, P. R. China.

PMID: 26105777
DOI: 10.1002/elps.201500089

Abstract

To investigate genetic diversity in Chinese populations, 706 unrelated male individuals from five ethnic groups (Han, Korean, Hui, Mongolian, and Tibetan, respectively) were analyzed with 17 Y-chromosomal STRs. The haplotype diversity was 0.99985 in the combined data. A total of 675 distinct haplotypes were observed, of which 649 were unique. Y-chromosome haplogroups in the five groups were also predicted with Y-STR haplotypes. Genetic distance between the five studied ethnic groups and other published groups was analyzed by analysis of molecular variance and visualized in a multidimensional scaling plot. In conclusion, the 17 Y-STR loci are highly polymorphic markers in the five groups and hence are very useful in forensic application, population genetics, and human evolution studies.

Keywords: Chinese ethnic group; Genetic distance; Genetic diversity; Haplogroup distribution; Y-chromosomal short tandem repeat.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics*
China
Chromosomes, Human, Y / genetics*
Ethnicity / genetics*
Haplotypes / genetics*
Humans
Male
Microsatellite Repeats / genetics*
Phylogeny