A "turn-on" silver nanocluster based fluorescent sensor for folate receptor detection and cancer cell imaging under visual analysis

Hong Jiang; Gang Xu; Yimin Sun; Weiwei Zheng; Xiangxiang Zhu; Baojuan Wang; Xiaojun Zhang; Guangfeng Wang

doi:10.1039/c5cc02061a

A "turn-on" silver nanocluster based fluorescent sensor for folate receptor detection and cancer cell imaging under visual analysis

Chem Commun (Camb). 2015 Jul 28;51(59):11810-3. doi: 10.1039/c5cc02061a.

Authors

Hong Jiang¹, Gang Xu, Yimin Sun, Weiwei Zheng, Xiangxiang Zhu, Baojuan Wang, Xiaojun Zhang, Guangfeng Wang

Affiliation

¹ Anhui Key Laboratory of Chem-Biosensing, College of Chemistry and Materials Science, Center for Nanoscience and Nanotechnology, Anhui Normal University, Wuhu, 241000, P. R. China. [email protected].

PMID: 26108636
DOI: 10.1039/c5cc02061a

Abstract

A novel terminal protection based label-free and "turn-on" fluorescent sensor for detection of folate receptors (FRs) and HeLa cells is developed by fluorescence resonance energy transfer (FRET) between single-walled carbon nanotubes (SWCNTs) and silver nanoclusters (AgNCs). Multilevel visual analysis (m(2)VA) was firstly proposed and applied in optimizing the experimental parameters.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Flow Cytometry
Fluorescence Resonance Energy Transfer
Fluorescent Dyes / chemistry*
Folate Receptors, GPI-Anchored / analysis*
Folate Receptors, GPI-Anchored / chemistry
HeLa Cells
Humans
Metal Nanoparticles / chemistry*
Nanotubes, Carbon / chemistry
Silver / chemistry*
Uterine Cervical Neoplasms / diagnosis*

Substances

Fluorescent Dyes
Folate Receptors, GPI-Anchored
Nanotubes, Carbon
Silver