Abstract
A new isoflavanone, 2,2'-epoxy-4'-methoxy-3,7-dihydroxyisoflavanone (1), and a new natural coumaranone, 2-hyroxy-2-(4'-methoxybenzyl)-6-methoxy-3-coumaranone (2), along with 26 known compounds, were first isolated from the trunk of Horsfieldia pandurifolia. Their structures were elucidated by the means of spectroscopic analysis. Compound 1 was assessed for its cytotoxicity against five human tumour lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that it has no activity.
Keywords:
Horsfieldia pandurifolia; Myristicaceae; isoflavanone.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzyl Compounds / chemistry
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Benzyl Compounds / isolation & purification
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Benzyl Compounds / pharmacology
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Cell Line, Tumor / drug effects
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Coumarins / chemistry
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Coumarins / isolation & purification
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Coumarins / pharmacology
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Drug Screening Assays, Antitumor / methods
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HL-60 Cells / drug effects
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Humans
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Isoflavones / chemistry*
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Isoflavones / isolation & purification
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Isoflavones / pharmacology
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Myristicaceae / chemistry*
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Spectrometry, Mass, Electrospray Ionization
Substances
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2,2'-epoxy-4'-methoxy-3,7-dihydroxyisoflavanone
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2-hyroxy-2-(4'-methoxybenzyl)-6-methoxy-3-coumaranone
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Benzyl Compounds
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Coumarins
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Isoflavones
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isoflavanone