Abstract
Well-defined star-like amphiphilic polymers composed of a β-cyclodextrin core, from which 21 hydrophobic poly(lactic acid) arms and hydrophilic poly(ethylene glycol) arms are grafted sequentially, form robust and uniform unimolecular micelles that are biocompatible and efficient in the delivery of anticancer drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Doxorubicin / administration & dosage
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Doxorubicin / chemistry
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Doxorubicin / pharmacology
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Drug Delivery Systems
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HeLa Cells
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Humans
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Hydrophobic and Hydrophilic Interactions
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Lactic Acid / chemical synthesis
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Lactic Acid / chemistry*
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Micelles
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Polyesters
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Polyethylene Glycols / chemical synthesis
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Polyethylene Glycols / chemistry*
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Polymers / chemical synthesis
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Polymers / chemistry*
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beta-Cyclodextrins / chemical synthesis
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beta-Cyclodextrins / chemistry*
Substances
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Antineoplastic Agents
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Micelles
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Polyesters
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Polymers
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beta-Cyclodextrins
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Lactic Acid
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Polyethylene Glycols
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poly(lactide)
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Doxorubicin