Value of the Nottingham Histological Grading Parameters and Nottingham Prognostic Index in Canine Mammary Carcinoma

Marta Santos; Carla Correia-Gomes; Ricardo Marcos; Andreia Santos; Augusto De Matos; Carlos Lopes; Patrícia Dias-Pereira

Value of the Nottingham Histological Grading Parameters and Nottingham Prognostic Index in Canine Mammary Carcinoma

Anticancer Res. 2015 Jul;35(7):4219-27.

Authors

Marta Santos¹, Carla Correia-Gomes², Ricardo Marcos¹, Andreia Santos³, Augusto De Matos⁴, Carlos Lopes⁵, Patrícia Dias-Pereira⁶

Affiliations

¹ Department of Microscopy, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal.
² Epidemiology Research Unit, Future Farming Systems, Scotland's Rural College, Inverness, U.K.
³ Faculty of Veterinary Medicine, Lusófona University of Humanities and Technologies, Lisbon, Portugal.
⁴ Department of Veterinary Clinics, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal Animal Science and Study Central, Food and Agrarian Sciences and Technologies Institute, University of Porto, Porto, Portugal.
⁵ Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal.
⁶ Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal [email protected].

PMID: 26124382

Abstract

Background/aim: In the past decade, the human Nottingham histological grade (NHG) has been applied to canine mammary carcinomas (CMC). The Nottingham Prognostic Index (NPI) enables identification of more aggressive human breast cancer. The prognostic value of grading parameters and NPI has never been detailed in CMC. The aim of the present study was to assess the prognostic value of NHG, its parameters and NPI.

Materials and methods: Univariable and multivariable analyses were used to assess the prognostic value of NHG, its parameters and NPI in a cohort of 59 dogs with CMC.

Results: Short disease-free interval and overall survival were associated with higher NHG, particularly of grade III. Only high nuclear pleomorphism score was significantly associated with poor survival. NPI exhibited a strong predictive value for disease progression.

Conclusion: NHG, nuclear pleomorphism and NPI have prognostic value in CMC. Nuclear pleomorphism is an independent prognostic factor. Evaluation of nuclear pleomorphism should be included in routine pathology reports.

Keywords: Canine mammary tumors; Nottingham histological grade; prognosis; survival.

MeSH terms

Animals
Disease Progression
Disease-Free Survival
Dogs
Female
Mammary Neoplasms, Animal / pathology*
Neoplasm Grading / methods
Prognosis
Retrospective Studies