Lamellar versus Micellar Structures-Aggregation Behavior of a Three-Chain Cationic Lipid Designed for Nonviral Polynucleotide Transfer

Christian Wölk; Christopher Janich; Dorota Pawlowska; Simon Drescher; Annette Meister; Gerd Hause; Bodo Dobner; Andreas Langner; Gerald Brezesinski

doi:10.1002/cphc.201500468

Lamellar versus Micellar Structures-Aggregation Behavior of a Three-Chain Cationic Lipid Designed for Nonviral Polynucleotide Transfer

Chemphyschem. 2015 Jul 20;16(10):2029. doi: 10.1002/cphc.201500468. Epub 2015 Jun 30.

Authors

Christian Wölk¹, Christopher Janich², Dorota Pawlowska³, Simon Drescher², Annette Meister⁴, Gerd Hause⁵, Bodo Dobner², Andreas Langner², Gerald Brezesinski³

Affiliations

¹ Martin Luther University Halle-Wittenberg, Institute of Pharmacy, Wolfgang-Langenbeck-Straße 4, 06120 Halle (Saale) (Germany). [email protected].
² Martin Luther University Halle-Wittenberg, Institute of Pharmacy, Wolfgang-Langenbeck-Straße 4, 06120 Halle (Saale) (Germany).
³ Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany).
⁴ Martin Luther University Halle-Wittenberg, Center for Structure and Dynamics of Proteins (MZP), Weinbergweg 22, 06120 Halle (Saale) (Germany).
⁵ Martin Luther University Halle-Wittenberg, Biocenter, Weinbergweg 22, 06120 Halle (Saale) (Germany).

PMID: 26129690
DOI: 10.1002/cphc.201500468

Abstract

The front cover artwork is provided by the groups of Prof. Bodo Dobner, Prof. Andreas Langner, and research partners Dr. Gerd Hause, Dr. Simon Drescher, and Dr. Annette Meister (MLU Halle-Wittenberg) as well as the group of Prof. Gerald Brezesinski (MPI of Colloids and Interfaces). The image shows the space-filling model of a three-chain amino-functionalized lipid designed for gene transfer and the preferred pH-dependent aggregates (multilamellar stacks, vesicles, rod-like micelles). The background shows a Cryo-TEM image of rod-like micelles. Read the full text of the article at 10.1002/cphc.201500188.