Identification of Mixed Lineage Leukemia Gene (MLL)/MLLT10 Fusion Transcripts by Reverse Transcription-PCR and Sequencing in a Case of AML With a FISH-Negative Cryptic MLL Rearrangement

Ann Lab Med. 2015 Jul;35(4):469-71. doi: 10.3343/alm.2015.35.4.469. Epub 2015 May 21.

Authors

Kiwoong Ko¹, Min-Jung Kwon¹, Hee-Yeon Woo¹, Hyosoon Park¹, Chang-Hun Park², Seung-Tae Lee², Sun-Hee Kim²

Affiliations

¹ Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
² Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adolescent
Bone Marrow / pathology
Exons
Gene Rearrangement
Histone-Lysine N-Methyltransferase / genetics*
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myeloid, Acute / diagnosis*
Leukemia, Myeloid, Acute / genetics
Male
Myeloid-Lymphoid Leukemia Protein / genetics*
Oncogene Proteins, Fusion / chemistry
Oncogene Proteins, Fusion / genetics*
Oncogene Proteins, Fusion / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
Transcription Factors / genetics*

Substances

KMT2A protein, human
MLLT10 protein, human
Oncogene Proteins, Fusion
Transcription Factors
Myeloid-Lymphoid Leukemia Protein
Histone-Lysine N-Methyltransferase