Abstract
A catalytic domino spirocyclization of 1,7-enynes with simple cycloalkanes and cyclo-1,3-dicarbonyls has been established via multiple C-C bond formations from alkynyl/alkenyl functions and dual α,α-C(sp(3))-H abstraction/insertion. The reaction involves addition, 6-exo-dig cyclization and radical coupling sequences under convenient catalytic conditions and provides a concise access to spiro cyclopenta[c]quinolines in good to excellent yields.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkanes / chemical synthesis
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Alkanes / chemistry
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Catalysis
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Cyclization
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Cyclopentanes / chemical synthesis*
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Cyclopentanes / chemistry
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Models, Molecular
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Quinolines / chemical synthesis*
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Quinolines / chemistry
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Spiro Compounds / chemical synthesis
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Spiro Compounds / chemistry
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Stereoisomerism
Substances
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Alkanes
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Cyclopentanes
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Quinolines
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Spiro Compounds