Genotypes of hepatitis B virus identified in patients tested prior to endoscopy from a Teaching Hospital in the Central Province of Sri Lanka

Ceylon Med J. 2015 Jun;60(2):62-4. doi: 10.4038/cmj.v60i2.8153.

Abstract

The present study was carried out to identify the hepatitis B virus (HBV) genotypes in six patients attending the surgical clinic who were positive for hepatitis B surface antigen. DNA was extracted from the serum of patients and subjected to a modified nested PCR to detect a 585 bp region within the S gene of the HBV genome. Positive PCR products were purified and sequenced via a cycle sequencing method. The sequence data were analyzed with reference sequences in the HepSEQ database to identify the particular HBV genotype of the samples. Nested PCR for the S gene of the HBV genome was positive in 2 out of 6 samples. The genotyping and sequence analysis of the PCR products showed HBV genotype A with a homology of 98% to the reference sequences in the HepSeq database.

MeSH terms

  • DNA, Viral / blood
  • DNA, Viral / genetics
  • Endoscopy
  • Genome, Viral / genetics
  • Genotype*
  • Hepatitis B / blood
  • Hepatitis B / virology*
  • Hepatitis B Surface Antigens / blood
  • Hepatitis B Surface Antigens / genetics*
  • Hepatitis B virus / genetics*
  • Hospitals, Teaching
  • Humans
  • Polymerase Chain Reaction
  • Preoperative Care
  • Protein Precursors / blood
  • Protein Precursors / genetics
  • Sequence Analysis, DNA / methods*
  • Sri Lanka
  • Viral Envelope Proteins / blood
  • Viral Envelope Proteins / genetics

Substances

  • DNA, Viral
  • Hepatitis B Surface Antigens
  • Protein Precursors
  • Viral Envelope Proteins
  • presurface protein 1, hepatitis B surface antigen