Keep the fire burning: Current avenues in the quest of treating mitochondrial disorders

Christin Tischner; Tina Wenz

doi:10.1016/j.mito.2015.06.002

Keep the fire burning: Current avenues in the quest of treating mitochondrial disorders

Mitochondrion. 2015 Sep:24:32-49. doi: 10.1016/j.mito.2015.06.002. Epub 2015 Jun 30.

Authors

Christin Tischner¹, Tina Wenz²

Affiliations

¹ Institute for Genetics and Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Str. 47A, 50674 Cologne, Germany.
² Institute for Genetics and Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Str. 47A, 50674 Cologne, Germany. Electronic address: [email protected].

PMID: 26134435
DOI: 10.1016/j.mito.2015.06.002

Abstract

Mitochondrial diseases are very heterogeneous in their genetic cause and clinical manifestation. During the last few decades progress has been made in the diagnosis of mitochondrial diseases, but an established therapy is so far lacking. Several experimental strategies targeting different points of intervention are currently being assessed world-wide. Numerous mouse models of OXPHOS disorders have become available enabling further optimization and validation of therapeutic strategies and paving the way for future clinical trials. In this review, we provide an update on current developments towards treatment as well as the potential and status of transition into therapeutic use.

Keywords: Experimental therapy; Mitochondrial disease; Mitochondrial medicine; Treatment.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biomedical Research / trends
Disease Models, Animal
Humans
Mitochondrial Diseases / diagnosis
Mitochondrial Diseases / genetics*
Mitochondrial Diseases / therapy*
Therapies, Investigational / methods*