The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model

Physiology (Bethesda). 2015 Jul;30(4):327-32. doi: 10.1152/physiol.00008.2015.

Abstract

C-peptide is produced, processed, and secreted with insulin, and appears to exert separate but intimately related effects. In this review, we address the existence of the C-peptide receptor, the interaction between C-peptide and insulin, and the potential physiological significance of proinsulin C-peptide.

Publication types

  • Review

MeSH terms

  • Animals
  • C-Peptide / metabolism*
  • Diabetic Angiopathies / metabolism
  • Diabetic Angiopathies / physiopathology
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / physiopathology
  • Humans
  • Insulin / metabolism*
  • Insulin Secretion
  • Insulin-Secreting Cells / metabolism*
  • Models, Biological*
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction

Substances

  • C-Peptide
  • Insulin
  • Receptors, G-Protein-Coupled