Design of a hyperpolarized (15)N NMR probe that induces a large chemical-shift change upon binding of calcium ions

Ryunosuke Hata; Hiroshi Nonaka; Yoichi Takakusagi; Kazuhiro Ichikawa; Shinsuke Sando

doi:10.1039/c5cc04597e

Design of a hyperpolarized (15)N NMR probe that induces a large chemical-shift change upon binding of calcium ions

Chem Commun (Camb). 2015 Aug 7;51(61):12290-2. doi: 10.1039/c5cc04597e.

Authors

Ryunosuke Hata¹, Hiroshi Nonaka, Yoichi Takakusagi, Kazuhiro Ichikawa, Shinsuke Sando

Affiliation

¹ Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan.

PMID: 26137859
DOI: 10.1039/c5cc04597e

Abstract

Ca(2+) is a fundamental metal ion for physiological functioning. Therefore, molecular probes for Ca(2+) analysis are required. Recently, a hyperpolarized NMR probe has emerged as a promising tool. Here, we report a new design of a hyperpolarized NMR probe for Ca(2+), which showed a large chemical shift change upon binding to Ca(2+) and was applied for Ca(2+) sensing in a hyperpolarized state.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding Sites
Calcium / analysis*
Calcium / chemistry*
Cations, Divalent / analysis
Cations, Divalent / chemistry
Magnetic Resonance Spectroscopy
Molecular Probes / analysis
Molecular Probes / chemistry*
Molecular Structure
Nitrogen Isotopes
Reference Standards

Substances

Cations, Divalent
Molecular Probes
Nitrogen Isotopes
Calcium