Abstract
Solution-phase synthesis of linear and cyclic β- and α,β-peptoids was coupled to photo-induced thiol-ene coupling reaction to readily access multivalent thioglycoclusters. A tetrameric cyclic β-peptoid scaffold displaying 1-thio-β-d-galactose or 1-thio-α-d-mannose has revealed by ITC experiments efficient binding potency for bacterial lectins LecA and BC2L-A, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Burkholderia cenocepacia / chemistry*
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Click Chemistry*
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Lectins / chemistry*
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Molecular Structure
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Peptoids / chemical synthesis*
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Peptoids / chemistry
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Photochemical Processes
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Pseudomonas aeruginosa / chemistry*
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Sulfhydryl Compounds / chemical synthesis*
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Sulfhydryl Compounds / chemistry
Substances
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Lectins
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Peptoids
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Sulfhydryl Compounds