Abstract
Biodegradable bridged silsesquioxane (BS) nanomaterials for two-photon-excited (TPE) imaging and therapy of breast cancer cells were described. A versatile synthesis was developed to design monodisperse tetra-alkoxysilylated diamino-diphenylbutadiene or Zn-porphyrin-based nanospheres of 30 to 50 nm.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Survival / drug effects
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Disulfides / chemistry*
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Dose-Response Relationship, Drug
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Humans
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MCF-7 Cells
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Microscopy, Fluorescence, Multiphoton / methods*
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Molecular Structure
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Nanoparticles / chemistry
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Nanoparticles / metabolism*
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Nanoparticles / therapeutic use*
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Organosilicon Compounds / chemical synthesis*
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Organosilicon Compounds / metabolism
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Organosilicon Compounds / therapeutic use*
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Particle Size
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / metabolism
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Photosensitizing Agents / therapeutic use
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Structure-Activity Relationship
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Surface Properties
Substances
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Disulfides
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Organosilicon Compounds
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Photosensitizing Agents