Deficient regulatory B cells in human chronic graft-versus-host disease

Adèle de Masson; Gérard Socié; Martine Bagot; Armand Bensussan; Jean-David Bouaziz

doi:10.1080/2162402X.2015.1016707

Deficient regulatory B cells in human chronic graft-versus-host disease

Oncoimmunology. 2015 Apr 1;4(7):e1016707. doi: 10.1080/2162402X.2015.1016707. eCollection 2015 Jul.

Authors

Adèle de Masson¹, Gérard Socié², Martine Bagot¹, Armand Bensussan³, Jean-David Bouaziz¹

Affiliations

¹ Service de Dermatologie; Hôpital Saint-Louis ; Paris, France ; INSERM UMRS 976; Laboratoire "Oncodermatology; Immunology and Cutaneous Stem Cells"; Université Paris VII Sorbonne Paris Cité; Hôpital Saint-Louis ; Paris, France.
² Service d'Hématologie Greffes; INSERM UMRS 1160; Université Paris VII Sorbonne Paris Cité; Hôpital Saint-Louis ; Paris, France.
³ INSERM UMRS 976; Laboratoire "Oncodermatology; Immunology and Cutaneous Stem Cells"; Université Paris VII Sorbonne Paris Cité; Hôpital Saint-Louis ; Paris, France.

Abstract

Human chronic graft-versus-host disease (cGVHD) is a frequent and disabling complication of allogeneic hematopoietic stem cell transplantation. Regulatory B cells (Bregs) are IL-10-producing B cells that are able to inhibit the innate and adaptive immune responses. We have recently demonstrated a defect in regulatory B cells in human cGVHD.

Keywords: allogeneic stem cell transplantation; chronic graft-versus-host disease; interleukin-10; regulatory B cells.

Publication types

Research Support, Non-U.S. Gov't