Novel FNDC3B and MECOM fusion and WT1 L378fs* 7 frameshift mutation in an acute myeloid leukaemia patient with cytomorphological and immunophenotypic features reminiscent of acute promyelocytic leukaemia

Huan-You Wang; Caitlin McMahon; Siraj M Ali; Lauren E Young; Somaye Yekezare; Jeffrey S Ross; Edward D Ball

doi:10.1111/bjh.13552

Novel FNDC3B and MECOM fusion and WT1 L378fs* 7 frameshift mutation in an acute myeloid leukaemia patient with cytomorphological and immunophenotypic features reminiscent of acute promyelocytic leukaemia

Br J Haematol. 2016 Mar;172(6):987-90. doi: 10.1111/bjh.13552. Epub 2015 Jul 6.

Authors

Huan-You Wang¹, Caitlin McMahon², Siraj M Ali², Lauren E Young², Somaye Yekezare³, Jeffrey S Ross², Edward D Ball⁴

Affiliations

¹ Department of Pathology, University of California San Diego, La Jolla, CA, USA. [email protected].
² Foundation Medicine, Inc., Cambridge, MA, USA.
³ Department of Pathology, University of California San Diego, La Jolla, CA, USA.
⁴ Division of Bone Marrow Transplantation, Department of Medicine, University of California San Diego, La Jolla, CA, USA.

PMID: 26147192
DOI: 10.1111/bjh.13552

No abstract available

Keywords: Wilms tumor 1; acute myeloid leukaemia; acute promyelocytic leukaemia; ectopic virus intergration site 1; fibronectin domain containing 3B.

Publication types

Case Reports
Letter

MeSH terms

Adult
DNA-Binding Proteins / genetics*
Fibronectins / genetics*
Frameshift Mutation*
Humans
Immunophenotyping
Leukemia, Myeloid, Acute / genetics*
Leukemia, Promyelocytic, Acute / pathology
MDS1 and EVI1 Complex Locus Protein
Male
Proto-Oncogenes / genetics*
Transcription Factors / genetics*
WT1 Proteins / genetics*

Substances

DNA-Binding Proteins
FNDC3B protein, human
Fibronectins
MDS1 and EVI1 Complex Locus Protein
MECOM protein, human
Transcription Factors
WT1 Proteins
WT1 protein, human