Abstract
A novel gold nanoparticle-peptide hybrid strategy was developed to intracellularly deliver a potent PKCδ inhibitor peptide for the treatment of acute lung injury. The gold nanoparticle-peptide hybrids showed good stability with high uptake, and demonstrated in vitro and in vivo efficacy. Our formulation strategy shows great promise in intracellular delivery of peptides.
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Line
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Disease Models, Animal
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Drug Carriers / chemistry*
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Gold / chemistry*
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Humans
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Metal Nanoparticles / chemistry*
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Microscopy, Confocal
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Particle Size
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Peptides / administration & dosage
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Peptides / chemistry*
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Protein Kinase C-delta / antagonists & inhibitors
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Protein Kinase C-delta / metabolism
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Protein Kinase Inhibitors / administration & dosage
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Protein Kinase Inhibitors / chemistry*
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Rats
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Reperfusion Injury / drug therapy
Substances
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Drug Carriers
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Peptides
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Protein Kinase Inhibitors
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Gold
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Protein Kinase C-delta