An easy and powerful access to 3,3',6,6'-tetrasubstituted 9,9'-spirobifluorene derivatives with tetrahedral orientation of the peripheral groups (i.e., -I, -CN, -NO2, -CH═O, -COOH, -C≡CH, -4-Py) was developed. The NMR and HRMS results are in agreement with the proposed formula and the solid-state molecular structures obtained by single-crystal X-ray diffraction. They form molecular solids self-assembled via exclusive hydrophobic interactions. Solid-state selection and adaptation can be obtained on the basis of variable compact packing of functional groups present on the 9,9'-spirobifluorene backbone.