Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading

Nat Biotechnol. 2015 Jul;33(7):694-6. doi: 10.1038/nbt.3274.
No abstract available

Publication types

  • Letter

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Chemistry, Pharmaceutical
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Immunoconjugates* / administration & dosage
  • Immunoconjugates* / chemistry
  • Immunoconjugates* / pharmacology
  • Immunoconjugates* / therapeutic use
  • Mice
  • Models, Molecular
  • Rats
  • Xenograft Model Antitumor Assays

Substances

  • Immunoconjugates